| Feature | Helios Neo 16 | Helios Neo 16S |
| Display | 16-inch WQXGA IPS, 240Hz, 1ms, 500 nits, 100% DCI-P3 | 16-inch WQXGA OLED, high contrast, true blacks |
| Screen-to-Body Ratio | Not specified | Over 90% |
| RAM | Up to 64GB DDR5 | Up to 64GB DDR5 |
| Storage | Up to 2TB PCIe Gen4 SSD | Up to 2TB PCIe Gen4 SSD |
| Cooling | 5th Gen AeroBlade™ 3D Fan, liquid metal thermal grease, vector heat pipes | Same as Helios Neo 16 AI |
| Keyboard & Lighting | 4-zone RGB keyboard, customizable RGB logo lighting | 4-zone RGB keyboard, customizable RGB logo lighting |
| Software & AI Tools | PredatorSense, Copilot key for system tools & AI features | Same as Helios Neo 16 AI |
| Connectivity | Thunderbolt 4, HDMI 2.1, Killer DoubleShot Pro (Wi-Fi 6E + Ethernet), USB Type-C | Same as Helios Neo 16 AI |
| Chassis | Standard chassis | Lightweight chassis |
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