high throughput sequencing

Indian scientists at ZSI have pioneered a groundbreaking method using DNA metabarcoding to decode spider-parasitoid relationships directly from egg sacs. This innovative approach, published in Scientific Reports, identified elusive parasitoid genera and unveiled hidden ecological connections. The research significantly contributes to biodiversity conservation and ecological understanding by making previously invisible interactions visible.

Scientists at Centre for DNA Fingerprinting and Diagnostics (CDFD), Department of Biotechnology, Ministry of Science and Technology said on Thursday that coffee has been found to be a cure for paroxysmal dyskinesia, a movement disorder.

Scientists have identified seven new genes that can cause X-linked intellectual disability, a disorder that predominantly affects men and can have highly variable clinical manifestations.

A team of genomic researchers from two institutes has identified 73 novel variants of the Covid-19 strain in Odisha, its head has said.The researchers are from CSIR-Institute of Genomics and Integrative Biology (IGIB), New Delhi and Institute of Medical Sciences and SUM Hospital, Bhubaneswar, he said.

A Centre for Cellular and Molecular Biology study has found that the Delta variant of coronavirus (SARS-CoV-2) could evade the human immune system more than other variants. CCMB researchers studied five different SARS-CoV-2 variants and how the human immune system responds to them.

The GenoPipe, a software tool developed by the bioinformatics centre of the Centre for development of Advanced Computing (C-DAC) is playing an important role in finding a cure for diseases such as tuberculosis and typhoid.

Researchers from Queen Mary, University of London have carried out the largest sequencing study of human disease to date, investigating the genetic basis of six autoimmune diseases.

IIT Delhi has developed a method to detect Covid-19 which will significantly reduce the cost of testing, making it affordable for a large population in the country. The method has been validated at ICMR with a sensitivity and specificity of 100% making IIT Delhi the first academic institute to have obtained the ICMR approval for a real-time PCR-based diagnostic assay.

For the first time, scientists have generated a 3D model of the human malaria parasite genome at three different stages in the parasite's life cycle, an advance that could help identify new anti-malaria drugs.

A study conducted by five researchers, including two from Odisha, stated that novel coronavirus (SARS-CoV-2) could develop resistance to Favipiravir, one of the few antiviral drugs extensively used in India and other countries against mild-to-moderate cases of Covid-19.

University of Utah biochemists have reported a new drug discovery tool against the Ebola virus – a molecule, known as a peptide mimic that displays a functionally critical region of the virus that is universally conserved in all known species of Ebola.

Researchers have identified a new Ebola drug target that will enable the discovery of therapies with the potential to treat any future epidemic, even if new virus strains emerge.

Almost 25% of the genome sequencing samples in the country came from Maharashtra, where the SARS-CoV-2’s Delta variant was first found around six months ago. Data from the Indian Covid Genome Surveillance shows Maharashtra has so far provided 11,968 samples — twice the number studied from other high incidence states such as Kerala and Delhi.