Driving

Hire a car but only to get out of the city

Word to the wise: Driving is completely different in Italy from anywhere else, as Italians seem to make their own rules.
Noteworthy for: Take Autostradas A1/A30 south to Napoli and Amalfi coast - arguably one of the most beautiful places in the world to drive a car.

In the world of the wheel, nothing quite compares to taking a sporty convertible down the Italian coast. While super-fast Autostrada navigate the length of the country, the situation inside its cities is confusing and stressful. Italians are in principle excellent drivers. They just don't care for the rules of the road, or other users. Red lights are considered meaningless and incur a cacophony of horns if you stop. Please do stop though, or you'll probably cause a much larger bang.
Meanwhile, avoid the Grande Raccordo Anulare (Autostrada A90) - the giant ring road that circles Rome - if you value your life. This toll-free orbital might be one of the quickest routes around the city. It is also effectively a race-track for truck drivers, who spare no mercy for hatchback cars, especially those with foreign registration plates.