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Liver damage starts silently: 7 lesser-known signs men and women must pay attention to

TOI Lifestyle Desk
| ETimes.in | Last updated on - Aug 8, 2025, 19:40 IST
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7 lesser-known signs of liver damage

The liver is one of the most vital organs in the body. It filters all of the blood in the body, produces bile, resists infection and regulates amino acids as well. However, it is also most susceptible to diseases, which are often called 'silent killers' because the signals are too subtle to be noticed in the beginning. According to the CDC, about 35.5 million people in the US suffer from liver disease. However, most of us chalk the signs up to causes such as ageing or stress. Below, find out 7 lesser-known signs of liver diseases that both men and women must pay attention to.


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Constant fatigue

Feeling tired all the time for no clear reason? It could be your liver waving a red flag. When your liver isn’t working properly, it struggles to filter toxins and support energy levels—leaving you drained, foggy, and just “off.” It’s more than tiredness—it’s your body asking for help.

An unhealthy liver will not be able to function well. This means that it will not filter the toxins in the blood effectively, leading to a feeling of general illnessand fatigue all the time.

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Skin discoloration

One of the most common signs of liver disease is skin discolouration or jaundice. This includes the development of yellow tints in the whites of the eyes and the skin. Additionally, it can also lead to darkened skin in areas such as the neck and the armpits, especially in women.

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Hepatic encephalopathy

Hepatic encephalopathy or an altered mental status are mostly considered signs of depression or a brain disease. However, did you know that these can also signal liver illness? The toxins in the liver, when unfiltered, can reach the brain and disrupt its functioning. This can manifest in the form of mood swings, forgetfulness, confusion and emotional and mental frustration.

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Skin problems

Liver diseases can present themselves in the body in the form of numerous skin conditions. These include palmar erythema, when the skin of the palms turns red; spider angiomas, when the blood vessels appear in spider-like clusters under the skin with red spots; inexplicable bruises and persistent itching caused by the accumulation of bile salts in the blood.

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Menstrual abnormalities

One of the very obvious signs for women in terms of liver disease is menstrual abnormalities. The instances of irregular cycles, heavy or light bleeding, missed periods can signal concerns. This is because the liver plays a role in metabolising and regulating hormones, and if it is not functioning properly, then it can affect your periods.

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Muscle weakness

Loss of muscles, also known as muscle wasting or sarcopenia, can happen when the liver is not properly processing proteins and nutrients. While most people attribute this to diet or exercise, if it is frequent and excessive, it could be a sign of liver disease. According to the National Institutes of Health, this is common in people with cirrhosis and other forms of liver disease.

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Dark urine and pale stools

Dark urine in the colours of amber to brown can be a sign of liver dysfunction. Liver eliminates the yellow compound called bilirubin through urine; however, when it is unable to do so, the compound accumulates, and darker urine is the result. Additionally, bile in the liver gives stool its colour. When it is not produced, the stool might be pale, grey or clay coloured.(image: canva)Also See: Hepatitis D Virus: WHO declares Hepatitis D virus as "carcinogenic": What does this mean amidst rising liver diseases​

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Digestive disturbances and abdominal discomfort

While occasional bloating or indigestion is common, persistent digestive issues can be a subtle sign of liver trouble. The liver plays a key role in producing bile, which helps digest fats. When it's not functioning optimally, you may experience nausea, a feeling of fullness after small meals, gas, or pain in the upper right side of the abdomen. Some people may also develop ascites—fluid buildup in the abdomen—causing visible swelling.Also See: Liver Damage Symptoms: 7 signs of liver damage seen in the feet​

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Common liver diseases to know

Common liver diseases include hepatitis (especially hepatitis A, B, and C), which involves liver inflammation often caused by viral infections. Fatty liver disease, both non-alcoholic (NAFLD) and alcoholic (AFLD), is increasingly prevalent due to obesity and alcohol use. Cirrhosis, often a result of chronic liver damage, can lead to liver failure. Liver cancer (hepatocellular carcinoma) is another serious concern. Hemochromatosis (iron overload) and Wilson’s disease (copper buildup) are genetic disorders affecting liver function. Early detection, lifestyle changes, and regular screening are crucial for effective management, particularly in high-risk populations.(Images: canva)

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Foods that harm liver

Certain foods can harm your liver over time, especially when consumed in excess. Processed foods high in trans fats, such as fried items, baked goods, and fast food, can lead to fatty liver disease. Excessive sugar intake—found in soda, candy, and sweetened cereals—can also strain the liver. Alcohol is one of the most damaging substances for liver health. Highly processed meats like bacon and sausages may contribute to inflammation. Foods high in salt and refined carbs can worsen liver function as well. For better liver health, limit these items and opt for whole, unprocessed foods rich in fiber and antioxidants.

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