Advances in modern cancer care have introduced powerful therapies that significantly improve survival. However, these treatments can also affect the skin, scalp and nails. These effects are commonly known as treatment-related side effects or adverse reactions. Studies show that nearly two out of three people receiving cancer therapy experience noticeable skin changes, many of which can impact daily comfort, confidence and overall wellbeing. While some reactions are mild and resolve naturally, others may progress, persist or, in rare cases, become serious enough to interrupt treatment. Because cancer therapy weakens the immune system, patients are also more prone to skin infections and allergic responses.Understanding how cancer treatments impact the skin Most cancer treatments have the potential to cause skin reactions. Chemotherapy, immunotherapy, radiation therapy and bone marrow transplantation can all affect the skin to varying degrees. The severity of these reactions depends on the specific drug, treatment duration and a patient’s individual biology. Oncodermatology, a developing branch of medicine, specialises in recognising and managing these skin-related issues. The aim of this subspeciality is to provide timely care that improves comfort, prevents complications and allows patients to continue their life-saving treatments with fewer disruptions.According to the National Cancer Institute, cancer treatments may cause skin and nail changes.Common skin symptoms during cancer treatment These are the most frequent skin symptoms seen in people undergoing cancer therapy, often including rashes, dryness, irritation, sensitivity, pigmentation changes, and other treatment-related dermatological reactions.Excessive dryness, itching and rashesBurning sensations and peeling of the skinFragile nails and pain in the fingertipsSwelling, redness and blisters on the hands and feetSoreness and ulcers inside the mouthIncreased sensitivity to sunlightPartial or complete hair lossSkin darkening, patches and thickeningWhat to expect when skin symptoms begin Before starting treatment, it is helpful to discuss potential skin reactions with your medical team. If you have a history of eczema, psoriasis or other chronic skin conditions, seeking advice from a dermatologist before therapy begins can help minimise flare-ups. When side effects appear, mild symptoms can often be managed at home using recommended creams, moisturisers and medications. Severe reactions are less common but may require hospital care, thorough evaluation, temporary pauses in treatment or, occasionally, intensive medical support.How to manage skin changes during cancer therapy How to manage skin symptoms Caring for the skin is an essential part of successful cancer treatment.Regular moisturising helps reduce discomfort and supports a healthy skin barrier.Moisturising is especially important for older adults and those with a history of dry skin conditions.Protecting the skin from sunlight is crucial because many cancer therapies increase UV sensitivity.Wearing sun-protective clothing during the day helps shield the skin from irritation and damage.Applying a broad-spectrum sunscreen can lower the risk of sunburn and long-term complications.Checking your skin regularly for new symptoms helps identify problems early.Informing your doctor as soon as you notice changes ensures timely management and supports uninterrupted cancer care.