Barcelona's goalkeeper, Marc-Andre ter Stegen, was taken off the field on a stretcher after injuring his knee during a 5-1 victory against Villarreal in the Spanish league on Sunday.
The injury occurred just before halftime when Ter Stegen's right knee buckled after he awkwardly landed while attempting to catch a high ball.
Both teams' players immediately called for medical assistance.
Barcelona president Joan Laporta suggested it might be a torn ligament but said more tests were needed. According to local media, Ter Stegen left the stadium in an ambulance and exited the hospital in a wheelchair.
"This injury makes us sad. I think the injury will be huge but we have to wait for more information," Barcelona coach Hansi Flick was quoted as saying by AP. "We have to accept it. It's not easy. It was an accident. It's very tough."
The 32-year-old German, who is one of Barcelona's captains, was replaced by Inaki Pena after the incident.