New side effect of GLP-1 drugs: Study links weight-loss drugs to chronic cough

GLP-1 drugs have emerged as a rare beacon of hope in America’s otherwise horizonless obesity epidemic. Drugs like Ozempic, Wegovy and Zepbound have been used by nearly 12% of Americans for weight loss, as per a RAND report.

While it has helped numerous celebrities such as Serena Williams and Meghan Trainor lose weight and achieve body positivity, it seems its effects include more than a slimmer waistline. Until now, users had reported various side effects of using GLP-1 drugs such as nausea, vomiting, constipation and diarrhoea, along with headaches, fatigue and changes to the skin.

But now, a new potential side effect has come to light, one that could make you think you are just under the weather.

New side effect of GLP-1 drugs

In a study published on Wednesday, in JAMA Otolaryngology, researchers analysed medical records from more than 2 million patients collected across the country between 2005 and 2025.




They identified 427,555 patients who had been prescribed the drugs to treat Type 2 diabetes. These drugs mimic the production of a hormone called glucagon-like peptide-1, which boosts insulin production, slows digestion and regulates appetite, thus lowering blood sugar and supporting weight management.

The team also observed 1.6 million Type 2 diabetes patients taking other common second-line diabetes medications.

The shocking results

While comparing the two groups, they found that patients taking a GLP-1 medication had up to a 29% higher risk of developing a chronic cough within the first five years of treatment. A chronic cough is one that lasts eight weeks or longer.

Additionally, these users were also more prone to be diagnosed with gastroesophageal reflux disease (GERD), which can trigger a dry cough.

“This cohort study suggests that there is an association between GLP-1 receptor agonist use and new diagnosis of chronic cough,” wrote the study authors.

However, they stressed that more research is needed to establish a definitive link and to better understand the biological mechanisms behind the new potential side effect.

Note: The information provided in this article is for educational purposes only and is not intended as medical advice. Always consult with a qualified healthcare professional before starting any new medication or treatment and before changing your diet or supplement regimen.



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