FIND and CSIR-IGIB partner to strengthen genomic surveillance of Coronavirus

MUMBAI:

FIND

, a global alliance for diagnostics, is partnering with CSIR-IGIB (

Institute of Genomics and Integrated Biology

) to strengthen genomic surveillance of SARS-CoV-2 in the country. The partnership aims to decentralize genomic surveillance of SARS-CoV-2, down to the district level by setting up `microlabs’ that enable sequencing, analysis and interpretation of sequencing data with minimal turnaround time and infrastructure limited settings, says a statement.

Point-of-care genome sequencing has gained more relevance with the emergence of Omicron, designated a VOC by the World Health Organization (WHO) on November 26, with the need for enhanced sequencing capacity becoming pivotal in tracking new variants and informing accurate tests and appropriate treatment. Point-of-care genome sequencing is designed to combine scale, speed and sensitivity, and is expected to become a gold standard for vigilance, analysis and control of pathogen spread.

The partnership will serve to optimize and scale the capacity needed to identify SARS-CoV-2 variants of concern (VOC) and variants of interest (VOI). It will also serve to identify genomic hotspots, and mutations associated with disease severity that are critical for surveillance and public health action.

Dr

Sanjay Sarin

, VP, Access at FIND said: “Omicron has shown us just how vital genomic sequencing is – for monitoring the evolution of the SARS-CoV-2 virus and identifying emerging mutations rapidly to inform public health action locally and globally. Building on our track record of strengthening diagnostic capacity in India as well as our established sequencing programme at FIND, this partnership with CSIR-IGIB will bring sequencing capabilities closer to patients, which means faster response times that can help keep everyone safe.”


Dr Rajesh Pandey principal scientist, CSIR-IGIB said: “MicroLabs based genome sequencing of pathogens would take labs to the people, allowing for rapid variant detection and prioritising sequencing of clinically relevant samples. This would advance a ‘hub-and-spoke’ model of genomic surveillance, comprising both --MegaLabs (high-throughput sequencing) and MicroLabs (high-priority sequencing). This is especially important as we make progress towards monitoring the ports of entry for possibly tracking of Omicron entry to India. In addition to VOC, understanding the genomic mutations underlying vaccination breakthrough is also equally important and merits tracking through network of MicroLabs.”

Prof Anurag Agrawal director CSIR-IGIB said: “Such efforts are important towards making India better prepared for genomic surveillance of pathogens, with trained genomics manpower, data management and data sharing.”

As a co-lead of the

Diagnostics Pillar

of the access to Covid-19 Tools (ACT) Accelerator, FIND is supporting India’s efforts towards establishment of a robust genomic surveillance system. With the second wave of Covid-19 highlighting the importance of focusing on hard-to-reach and rural populations, point-of-care genome sequencing is essential to track the evolution of the virus, it added.


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